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KMID : 0616120180490030246
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 3 p.246 ~ p.254
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Skin Safety Evaluation of Pectin Lyase-modified Red Ginseng Extract (GS-E3D)
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Pyo Mi-Kyung
Lee Gyeong-Hee
Cha Seon-Woo
Park Ki-Young
Lee Ki-Moo
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Abstract
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Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D. Single oral toxicity, single dermal toxicity, bovine corneal opacity and permeability (BCOP) assay, skin irritation test with SkinEthicTM human epidermis model, skin sensitization local lymph node assay, and human patch test, were examined. The oral and dermal LD50 value of GS-E3D was over 2,000 mg/kg in rats. GS-E3D was identified as a non-irritant to skin in BCOP assay, human epidermis models, and patch test from the 32 human subjects. The skin sensitization potential of GS-E3D was less than 25% in local lymph node assay. These results indicate that GS-E3D can be used as a safe ingredient without adverse effects in various skin care products.
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KEYWORD
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GS-E3D, Panax ginseng, Safety, Skin irritation, Human patch test
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